SpO₂ cannot be recomputed from one plethysmogram, so its timing comes from events that change the PLETH abruptly. SpO₂ lags the recorded PLETH by about 4 s and then smooths over roughly 10–20 s.
During low perfusion SpO₂ mostly holds its last value rather than blanking (55–70% of 5–20 s episodes); when the probe comes off it blanks within about a second.
For 4,281 blood gases, reading the monitor when the blood was drawn rather than at the lab stamp makes changes in end-tidal CO₂ track changes in arterial CO₂ far better (within-patient correlation 0.74 against 0.54), and agreement peaks exactly at the estimated draw. Oximetry shows the same timing (agreement peaks at the draw), but the 100% ceiling hides the size of the oximetry gradient for three gases in four.
SpO₂ is blanked or frozen when the pulse is lost and returns about 5.5 s after the pulse comes back; PLETH artefacts move SpO₂ and PLETH_HR within seconds.