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The Primus stamp step at each airway-pressure pause

Measured directly at 2,491 pauses in 1,021 recordings: where CO₂ carries on through the AWP pause (74%), the Primus stamps barely step (median −1 ms, p10–p90 −164 to +187 ms, close to the no-pause controls); where CO₂ stops too (26%), they step by up to seconds. No step undoes the drift built up since the last pause.

Date 2026-10-19
Status current
Methods One event, two clocks
Techniques Windowed cross-correlation, Null controls
Clocks Primus clock, SNUADC sample clock, Recorder PC clock
Devices Primus anaesthesia machine, SNUADC
Variables Airway pressure (Primus), Capnogram (Primus)

Background

At each AWP pause (about 21 s every 7,230 s; The Primus AWP stops for about 21 s every 7,230 s) the Primus stamps step against the SNUADC. The 10-minute windows of The Primus ventilator against SNUADC, by breaths see these steps only through fitted lines, and windows that straddle a pause mix two lags.

Data

All 6,388 recordings were read; 1,021 had AWP, CVP, at least one AWP pause with enough breathing either side, and at least 200 mechanical breaths. 2,491 of their 3,665 pauses were measurable; up to two control moments per recording at least 25 minutes from any pause.

Method

The airway-pressure-to-CVP lag in 2-minute windows (stepped by 1 minute) for 20 minutes before and after each gap, with the SNUADC on its stamp model; a line on each side, and the step as their difference at the middle of the gap. Recorded with each step: gap length, drift built up since the previous pause, the Primus's small whole-sample corrections nearby, whether CO₂ also stops, and whether a SNUADC reset falls within 20 minutes. Controls: the same measurement where no pause is near.

Results

Pauses Count Step, median (p10–p90) Within 150 ms
CO₂ carries on 1,846 −1 ms (−164 to +187) 76%
CO₂ stops too 645 −269 ms (−1,965 to +1,609) 8%
Controls, no pause −10 ms (−144 to +162)
  • Unrelated to the drift built up since the previous pause (r = −0.03; 0.3% of it taken back), to the gap's length (r = −0.05) and to the small whole-sample corrections (r = 0.00).
  • A nearby SNUADC reset does not enlarge the step (median |step| 87 ms with, 119 ms without).
  • Precision: a median standard error of 37 ms per step.
Two histograms of step size from −2 to +2 s. The blue one is a tall narrow peak at zero inside a grey band of about ±150 ms; the orange one is flat across the whole range with spikes at both edges.
The Primus stamp step at each AWP pause against the SNUADC, measured from 20 minutes of breath-matched lag either side. Blue: pauses where CO₂ carries on (1,846), almost all within the spread of the no-pause controls (grey band, p10–p90). Orange: pauses where CO₂ stops too (645), spread over seconds; values beyond ±2 s are gathered at the edges.

Discussion

The regular AWP pause is not a clock correction in itself: when the CO₂ stream carries on, the stamps keep their timing. The large steps come when both waveforms stop, which looks like the recorder losing and re-opening the Primus connection and re-anchoring its stamps to the PC. Even so, synchronisation is best with a fresh offset and slope at every AWP pause, not only at breaks: predicting each 10-minute window from the others gives a median error of 55 ms that way, against 82 ms with new lines only at breaks and 64 ms with lines joined at the regular pauses (1,067 recordings, tools/primus_pause_aware.py). The regular pauses are small steps on average, but not small enough to ignore.

Observations it supports

Observation Status Summary
The Primus AWP stops for about 21 s every 7,230 s established In 5,502 recordings the Primus airway-pressure waveform has gaps of 19–23.5 s (whole messages of 0.48 s, mostly 21.12 s) that recur every 7,230 s, the Primus's correction interval; a clock correction follows about 21.6 s after. The CO₂ waveform carries on through 90% of them. The 21 s of AWP are lost, not merely re-stamped.

Limitations

The step includes any change in the physiological airway-to-CVP delay across the pause. Pauses within 20 minutes of a recording's edge, or with too little breathing either side, are not measured.

Open questions

  • What the stamps re-anchor to when both waveforms stop (weakly supported hypothesis). Steps of up to seconds come where AWP and CO₂ stop together. A re-opened connection re-anchoring the stamps to the PC's arrival time is the working explanation; the recorder's message log around those gaps would test it.

Code